Germany suffered a major blow ahead of the World Cup finals on Saturday as an ankle injury ruled midfielder Marco Reus out of the tournament, the German Federation announced.

The 25-year-old Borussia Dortmund star, scorer of seven goals in 21 appearances for Germany, suffered a slight tear to ankle ligaments in Friday's 6-1 friendly win over Armenia.

Coach Joachim Loew called up the 22-year-old Shkodran Mustafi, capped just once and who plays for Serie A side Sampdoria.

The German squad fly out to Brazil later on Saturday.