Germany's World Cup winner Mario Goetze has been ruled out Borussia Dortmund's Champions League clash at Real Madrid on Wednesday with a knee injury.

Borussia has confirmed the 24-year-old will miss the match at the Bernabeu, because of a light knee injury, with leaders Dortmund holding a two-point advantage over Real.

The winner of the clash in Madrid will qualify top of Group F with both teams already through to the last 16.

Dortmund jetted to Madrid just one shy of the 20-goal record three teams -- Manchester United, Real Madrid and Barcelona -- have previously tallied in the Champions League group stages.

Two of those, United, in 1998/99, and Real, who achieved 'La Decima' -- a tenth European crown -- in 2013/14, went on to win that season's European title.

Dortmund has said Goetze should be fit for their Bundesliga clash this weekend against Cologne.