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| 1st(1st leg) | FK Tomori Berat | - | KF Skënderbeu | 0:3 | ||
| 2nd (2nd leg) | KF Skënderbeu | - | FK Tomori Berat | 2:0 | ||
| 1st(1st leg): 06/09/2015 16:00 | 2nd (2nd leg): 09/10/2015 14:30 | Winner: KF Skënderbeu | ||||
| 1st(1st leg) | KS Korabi Peshkopi | - | FK Partizani | 0:5 | ||
| 2nd (2nd leg) | FK Partizani | - | KS Korabi Peshkopi | 0:2 | ||
| 1st(1st leg): 16/09/2015 12:00 | 2nd (2nd leg): 29/09/2015 12:00 | Winner: FK Partizani | ||||
| 1st(1st leg) | KS Besa | - | KF Laçi | 1:3 | ||
| 2nd (2nd leg) | KF Laçi | - | KS Besa | 1:1 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: KF Laçi | ||||
| 1st(1st leg) | KS Pogradeci | - | FK Vllaznia | 1:1 | ||
| 2nd (2nd leg) | FK Vllaznia | - | KS Pogradeci | 4:0 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: FK Vllaznia | ||||
| 1st(1st leg) | KS Shkumbini | - | KF Apolonia Fier | 2:2 | ||
| 2nd (2nd leg) | KF Apolonia Fier | - | KS Shkumbini | 1:0 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: KF Apolonia Fier | ||||
| 1st(1st leg) | Dinamo Tiranë | - | KF Bylis Ballsh | 0:1 | ||
| 2nd (2nd leg) | KF Bylis Ballsh | - | Dinamo Tiranë | 6:0 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: KF Bylis Ballsh | ||||
| 1st(1st leg) | Luftëtari Gjirokastër | - | KF Lushnja | 0:1 | ||
| 2nd (2nd leg) | KF Lushnja | - | Luftëtari Gjirokastër | 3:0 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: KF Lushnja | ||||
| 1st(1st leg) | Sopoti Librazhd | - | Butrinti Sarandë | 5:0 | ||
| 2nd (2nd leg) | Butrinti Sarandë | - | Sopoti Librazhd | 2:0 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: Sopoti Librazhd | ||||
| 1st(1st leg) | KF Naftëtari Kuçovë | - | FK Kukësi | 3:1 | ||
| 2nd (2nd leg) | FK Kukësi | - | KF Naftëtari Kuçovë | 4:1 aet | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: FK Kukësi | ||||
| 1st(1st leg) | Erzeni Shijak | - | KF Tiranë | 0:1 | ||
| 2nd (2nd leg) | KF Tiranë | - | Erzeni Shijak | 2:0 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 29/09/2015 14:30 | Winner: KF Tiranë | ||||
| 1st(1st leg) | KF Gramshi | - | Flamurtari Vlorë | 1:2 | ||
| 2nd (2nd leg) | Flamurtari Vlorë | - | KF Gramshi | 3:2 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: Flamurtari Vlorë | ||||
| 1st(1st leg) | KF Ada Velipojë | - | KF Teuta Durrës | 1:5 | ||
| 2nd (2nd leg) | KF Teuta Durrës | - | KF Ada Velipojë | 6:1 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: KF Teuta Durrës | ||||
| 1st(1st leg) | KS Kamza | - | KF Elbasani | 4:2 | ||
| 2nd (2nd leg) | KF Elbasani | - | KS Kamza | 1:1 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: KS Kamza | ||||
| 1st(1st leg) | KS Burreli | - | KF Tërbuni Pukë | 0:0 | ||
| 2nd (2nd leg) | KF Tërbuni Pukë | - | KS Burreli | 2:0 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: KF Tërbuni Pukë | ||||
| 1st(1st leg) | KS Kastrioti | - | KS Besëlidhja Lezhë | 1:0 | ||
| 2nd (2nd leg) | KS Besëlidhja Lezhë | - | KS Kastrioti | 2:1 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: KS Kastrioti | ||||
| 1st(1st leg) | KS Iliria | - | KF Adriatiku Mamurrasi | 1:0 | ||
| 2nd (2nd leg) | KF Adriatiku Mamurrasi | - | KS Iliria | 0:2 | ||
| 1st(1st leg): 16/09/2015 15:00 | 2nd (2nd leg): 30/09/2015 14:30 | Winner: KS Iliria | ||||
