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| 1st(1st leg) | Sopoti Librazhd | - | KF Skënderbeu | 1:1 | ||
| 2nd (2nd leg) | KF Skënderbeu | - | Sopoti Librazhd | 2:0 | ||
| 1st(1st leg): 12/10/2015 13:30 | 2nd (2nd leg): 15/11/2015 12:00 | Winner: KF Skënderbeu | ||||
| 1st(1st leg) | KF Tërbuni Pukë | - | Flamurtari Vlorë | 0:1 | ||
| 2nd (2nd leg) | Flamurtari Vlorë | - | KF Tërbuni Pukë | 5:0 | ||
| 1st(1st leg): 21/10/2015 13:30 | 2nd (2nd leg): 04/11/2015 13:00 | Winner: Flamurtari Vlorë | ||||
| 1st(1st leg) | KS Kastrioti | - | KF Tiranë | 1:5 | ||
| 2nd (2nd leg) | KF Tiranë | - | KS Kastrioti | 2:1 | ||
| 1st(1st leg): 21/10/2015 13:30 | 2nd (2nd leg): 04/11/2015 13:00 | Winner: KF Tiranë | ||||
| 1st(1st leg) | KS Iliria | - | FK Kukësi | 0:5 | ||
| 2nd (2nd leg) | FK Kukësi | - | KS Iliria | 3:1 | ||
| 1st(1st leg): 21/10/2015 13:30 | 2nd (2nd leg): 04/11/2015 13:00 | Winner: FK Kukësi | ||||
| 1st(1st leg) | KS Kamza | - | KF Teuta Durrës | 0:1 | ||
| 2nd (2nd leg) | KF Teuta Durrës | - | KS Kamza | 3:0 | ||
| 1st(1st leg): 21/10/2015 13:30 | 2nd (2nd leg): 04/11/2015 13:00 | Winner: KF Teuta Durrës | ||||
| 1st(1st leg) | KF Lushnja | - | FK Partizani | 1:3 | ||
| 2nd (2nd leg) | FK Partizani | - | KF Lushnja | 3:0 | ||
| 1st(1st leg): 21/10/2015 13:30 | 2nd (2nd leg): 04/11/2015 13:00 | Winner: FK Partizani | ||||
| 1st(1st leg) | KF Bylis Ballsh | - | KF Laçi | 0:0 | ||
| 2nd (2nd leg) | KF Laçi | - | KF Bylis Ballsh | 3:2 | ||
| 1st(1st leg): 21/10/2015 13:30 | 2nd (2nd leg): 04/11/2015 13:00 | Winner: KF Laçi | ||||
| 1st(1st leg) | KF Apolonia Fier | - | FK Vllaznia | 0:0 | ||
| 2nd (2nd leg) | FK Vllaznia | - | KF Apolonia Fier | 2:1 | ||
| 1st(1st leg): 28/10/2015 13:30 | 2nd (2nd leg): 04/11/2015 13:00 | Winner: FK Vllaznia | ||||
