1st(1st leg) Butrinti Sarandë - KF Skënderbeu 1:1
2nd (2nd leg) KF Skënderbeu - Butrinti Sarandë 8:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KF Skënderbeu
1st(1st leg) FK Tomori Berat - FK Kukësi 0:3
2nd (2nd leg) FK Kukësi - FK Tomori Berat 1:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: FK Kukësi
1st(1st leg) Sopoti Librazhd - KF Tiranë 1:1
2nd (2nd leg) KF Tiranë - Sopoti Librazhd 7:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KF Tiranë
1st(1st leg) Turbina Cërrik - KF Laçi 0:2
2nd (2nd leg) KF Laçi - Turbina Cërrik 3:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KF Laçi
1st(1st leg) KS Shkumbini - KF Bylis Ballsh 1:3
2nd (2nd leg) KF Bylis Ballsh - KS Shkumbini 4:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KF Bylis Ballsh
1st(1st leg) KF Elbasani - Luftëtari Gjirokastër 0:1
2nd (2nd leg) Luftëtari Gjirokastër - KF Elbasani 2:2
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: Luftëtari Gjirokastër
1st(1st leg) Dinamo Tiranë - KS Pogradeci 2:1
2nd (2nd leg) KS Pogradeci - Dinamo Tiranë 1:1
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: Dinamo Tiranë
1st(1st leg) KF Lushnja - KF Apolonia Fier 1:3
2nd (2nd leg) KF Apolonia Fier - KF Lushnja 1:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KF Apolonia Fier
1st(1st leg) FC Kevitan - FK Partizani 1:5
2nd (2nd leg) FK Partizani - FC Kevitan 4:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 06/10/2016 13:00 Winner: FK Partizani
1st(1st leg) FK Shënkolli - KF Teuta Durrës 0:0
2nd (2nd leg) KF Teuta Durrës - FK Shënkolli 2:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KF Teuta Durrës
1st(1st leg) KF Adriatiku Mamurrasi - FK Vllaznia 0:3
2nd (2nd leg) FK Vllaznia - KF Adriatiku Mamurrasi 4:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: FK Vllaznia
1st(1st leg) KS Iliria - Flamurtari Vlorë 1:0
2nd (2nd leg) Flamurtari Vlorë - KS Iliria 6:0
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: Flamurtari Vlorë
1st(1st leg) KS Besa - KF Tërbuni Pukë 1:1
2nd (2nd leg) KF Tërbuni Pukë - KS Besa 4:1
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KF Tërbuni Pukë
1st(1st leg) KS Kamza - KS Korabi Peshkopi 1:1
2nd (2nd leg) KS Korabi Peshkopi - KS Kamza 0:2
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KS Kamza
1st(1st leg) KS Burreli - KS Kastrioti 3:1
2nd (2nd leg) KS Kastrioti - KS Burreli 4:1
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KS Kastrioti
1st(1st leg) Erzeni Shijak - KS Besëlidhja Lezhë 1:3
2nd (2nd leg) KS Besëlidhja Lezhë - Erzeni Shijak 2:2
1st(1st leg): 28/09/2016 15:00 2nd (2nd leg): 05/10/2016 13:00 Winner: KS Besëlidhja Lezhë