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| 1st(1st leg) | Colón de Santa Fe | - | Belgrano de Córdoba | 0:1 (0:1) | ||
| 2nd (2nd leg) | Belgrano de Córdoba | - | Colón de Santa Fe | 1:1 (0:1) | ||
| 1st(1st leg): 28/11/2015 20:00 | 2nd (2nd leg): 05/12/2015 22:00 | Winner: Belgrano de Córdoba | ||||
| 1st(1st leg) | Olimpo de Bahía Blanca | - | Estudiantes | 0:1 (0:1) | ||
| 2nd (2nd leg) | Estudiantes | - | Olimpo de Bahía Blanca | 4:0 (1:0) | ||
| 1st(1st leg): 28/11/2015 21:00 | 2nd (2nd leg): 06/12/2015 00:30 | Winner: Estudiantes | ||||
| 1st(1st leg) | Lanús | - | Gimnasia de La Plata | 1:0 (0:0) | ||
| 2nd (2nd leg) | Gimnasia de La Plata | - | Lanús | 1:2 (1:1) | ||
| 1st(1st leg): 28/11/2015 23:15 | 2nd (2nd leg): 07/12/2015 00:30 | Winner: Lanús | ||||
| 1st(1st leg) | Aldosivi | - | Banfield | 2:3 (2:1) | ||
| 2nd (2nd leg) | Banfield | - | Aldosivi | 1:1 (0:0) | ||
| 1st(1st leg): 30/11/2015 00:30 | 2nd (2nd leg): 05/12/2015 21:00 | Winner: Banfield | ||||
