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| 24/08/2017 | 19:00 | Cercle Brugge | - | KSV Temse | 3:1 (0:1, 1:1) aet | |
| 26/08/2017 | 15:00 | Royal Tilleur FC | - | Union Saint-Gilloise | 1:4 (0:3) | |
| 17:00 | KFC St. Lenaarts | - | Lierse SK | 0:2 (0:1) | ||
| 18:00 | RWDM Brussels FC | - | UR La Louvière Centre | 4:5 (0:0, 1:1, 1:1) pso | ||
| 18:00 | Eendracht Wervik | - | Rupel Boom FC | 2:3 | ||
| 18:30 | KSV Oudenaarde | - | AFC Tubize | 3:4 (1:0, 1:1, 3:3) pso | ||
| 19:00 | KSV Roeselare | - | Bilzerse VV | 3:1 (0:0) | ||
| 19:00 | KFC Oosterzonen | - | KFCO Beerschot Wilrijk | 2:3 (1:0) | ||
| 19:00 | Lommel SK | - | KFC Dessel Sport | 2:0 (2:0) | ||
| 19:00 | Tempo Overijse | - | RES Durbuysienne | 2:3 (0:2) | ||
| 27/08/2017 | 14:00 | KVC Westerlo | - | KSC Menen | 4:0 (1:0) | |
| 15:00 | Olympia Wijgmaal | - | Bocholter VV | 0:1 (0:0) | ||
| 15:00 | Oud-Heverlee Leuven | - | FC Turnhout | 8:0 (5:0) | ||
| 15:00 | ASV Geel | - | KFC Duffel | 3:0 (2:0) | ||
| 15:00 | Eendracht Aalst | - | RFC Liège | 1:2 (1:1) | ||
| 15:00 | Royal Knokke FC | - | KSK Heist | 2:5 (1:3) |
