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| 1st(1st leg) | CD Guabirá | - | Club Aurora | 1:0 (0:0) | ||
| 2nd (2nd leg) | Club Aurora | - | CD Guabirá | 0:0 (0:0) | ||
| 1st(1st leg): 05/05/2018 01:00 | 2nd (2nd leg): 13/05/2018 20:00 | Winner: CD Guabirá | ||||
| 1st(1st leg) | Royal Pari | - | Universitario de Sucre | 1:0 (0:0) | ||
| 2nd (2nd leg) | Universitario de Sucre | - | Royal Pari | 0:2 (0:1) | ||
| 1st(1st leg): 05/05/2018 20:00 | 2nd (2nd leg): 13/05/2018 22:15 | Winner: Royal Pari | ||||
| 1st(1st leg) | Sport Boys Warnes | - | Real Potosí | 0:0 (0:0) | ||
| 2nd (2nd leg) | Real Potosí | - | Sport Boys Warnes | 1:2 (1:1) | ||
| 1st(1st leg): 05/05/2018 22:15 | 2nd (2nd leg): 13/05/2018 20:00 | Winner: Sport Boys Warnes | ||||
