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| 1st(1st leg) | Atlético Mineiro | - | Ferroviário - CE | 4:0 (3:0) | ||
| 2nd (2nd leg) | Ferroviário - CE | - | Atlético Mineiro | 2:2 (2:0) | ||
| 1st(1st leg): 04/04/2018 23:30 | 2nd (2nd leg): 19/04/2018 01:45 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Athletico Paranaense | - | São Paulo FC | 2:1 (1:0) | ||
| 2nd (2nd leg) | São Paulo FC | - | Athletico Paranaense | 2:2 (2:1) | ||
| 1st(1st leg): 05/04/2018 01:45 | 2nd (2nd leg): 19/04/2018 23:15 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Avaí - SC | - | Goiás - GO | 2:2 (0:0) | ||
| 2nd (2nd leg) | Goiás - GO | - | Avaí - SC | 2:0 (1:0) | ||
| 1st(1st leg): 11/04/2018 23:30 | 2nd (2nd leg): 18/04/2018 23:30 | Winner: Goiás - GO | ||||
| 1st(1st leg) | Internacional | - | Vitória - BA | 2:1 (1:1) | ||
| 2nd (2nd leg) | Vitória - BA | - | Internacional | 4:3 (0:0, 1:0) pso | ||
| 1st(1st leg): 11/04/2018 23:30 | 2nd (2nd leg): 19/04/2018 23:15 | Winner: Vitória - BA | ||||
| 1st(1st leg) | Ponte Preta | - | Náutico - PE | 3:0 (3:0) | ||
| 2nd (2nd leg) | Náutico - PE | - | Ponte Preta | 1:0 (0:0) | ||
| 1st(1st leg): 12/04/2018 01:45 | 2nd (2nd leg): 19/04/2018 01:45 | Winner: Ponte Preta | ||||
