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| 1st(1st leg) | Young Africans | - | Al Ahly SC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Al Ahly SC | - | Young Africans | 2:1 (0:0) | ||
| 1st(1st leg): 09/04/2016 14:00 | 2nd (2nd leg): 20/04/2016 18:30 | Winner: Al Ahly SC | ||||
| 1st(1st leg) | ASEC Mimosas | - | Al Ahly Tripolis | 2:0 (0:0) | ||
| 2nd (2nd leg) | Al Ahly Tripolis | - | ASEC Mimosas | 2:1 (1:1) | ||
| 1st(1st leg): 09/04/2016 16:30 | 2nd (2nd leg): 20/04/2016 16:00 | Winner: ASEC Mimosas | ||||
| 1st(1st leg) | Al Merrikh SC | - | ES Sétif | 2:2 (1:2) | ||
| 2nd (2nd leg) | ES Sétif | - | Al Merrikh SC | 0:0 (0:0) | ||
| 1st(1st leg): 09/04/2016 18:00 | 2nd (2nd leg): 19/04/2016 19:00 | Winner: ES Sétif | ||||
| 1st(1st leg) | Stade Malien | - | ZESCO United | 1:3 (1:1) | ||
| 2nd (2nd leg) | ZESCO United | - | Stade Malien | 2:1 (1:0) | ||
| 1st(1st leg): 09/04/2016 19:00 | 2nd (2nd leg): 19/04/2016 14:00 | Winner: ZESCO United | ||||
| 1st(1st leg) | Zamalek | - | MO Béjaïa | 2:0 (0:0) | ||
| 2nd (2nd leg) | MO Béjaïa | - | Zamalek | 1:1 (0:0) | ||
| 1st(1st leg): 09/04/2016 19:00 | 2nd (2nd leg): 19/04/2016 18:00 | Winner: Zamalek | ||||
| 1st(1st leg) | Wydad AC | - | TP Mazembe | 2:0 (1:0) | ||
| 2nd (2nd leg) | TP Mazembe | - | Wydad AC | 1:1 | ||
| 1st(1st leg): 09/04/2016 19:30 | 2nd (2nd leg): 20/04/2016 14:30 | Winner: Wydad AC | ||||
| 1st(1st leg) | AS Vita Club | - | Mamelodi Sundowns | 1:0 (0:0) | ||
| 2nd (2nd leg) | Mamelodi Sundowns | - | AS Vita Club | 2:1 (1:1) | ||
| 1st(1st leg): 10/04/2016 15:30 | 2nd (2nd leg): 20/04/2016 18:30 | Winner: AS Vita Club | ||||
| 1st(1st leg) | Enyimba Aba | - | Étoile du Sahel | 3:0 (1:0) | ||
| 2nd (2nd leg) | Étoile du Sahel | - | Enyimba Aba | 3:4 (1:0, 3:0) pso | ||
| 1st(1st leg): 10/04/2016 16:00 | 2nd (2nd leg): 20/04/2016 19:00 | Winner: Enyimba Aba | ||||
