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| 1st(1st leg) | Paris Saint-Germain | - | Chelsea FC | 2:1 (1:1) | ||
| 2nd (2nd leg) | Chelsea FC | - | Paris Saint-Germain | 1:2 (1:1) | ||
| 1st(1st leg): 16/02/2016 19:45 | 2nd (2nd leg): 09/03/2016 19:45 | Winner: Paris Saint-Germain | ||||
| 1st(1st leg) | SL Benfica | - | Zenit St. Petersburg | 1:0 (0:0) | ||
| 2nd (2nd leg) | Zenit St. Petersburg | - | SL Benfica | 1:2 (0:0) | ||
| 1st(1st leg): 16/02/2016 19:45 | 2nd (2nd leg): 09/03/2016 17:00 | Winner: SL Benfica | ||||
| 1st(1st leg) | KAA Gent | - | VfL Wolfsburg | 2:3 (0:1) | ||
| 2nd (2nd leg) | VfL Wolfsburg | - | KAA Gent | 1:0 (0:0) | ||
| 1st(1st leg): 17/02/2016 19:45 | 2nd (2nd leg): 08/03/2016 19:45 | Winner: VfL Wolfsburg | ||||
| 1st(1st leg) | AS Roma | - | Real Madrid | 0:2 (0:0) | ||
| 2nd (2nd leg) | Real Madrid | - | AS Roma | 2:0 (0:0) | ||
| 1st(1st leg): 17/02/2016 19:45 | 2nd (2nd leg): 08/03/2016 19:45 | Winner: Real Madrid | ||||
| 1st(1st leg) | Arsenal FC | - | FC Barcelona | 0:2 (0:0) | ||
| 2nd (2nd leg) | FC Barcelona | - | Arsenal FC | 3:1 (1:0) | ||
| 1st(1st leg): 23/02/2016 19:45 | 2nd (2nd leg): 16/03/2016 19:45 | Winner: FC Barcelona | ||||
| 1st(1st leg) | Juventus | - | Bayern München | 2:2 (0:1) | ||
| 2nd (2nd leg) | Bayern München | - | Juventus | 4:2 (0:2, 2:2) aet | ||
| 1st(1st leg): 23/02/2016 19:45 | 2nd (2nd leg): 16/03/2016 19:45 | Winner: Bayern München | ||||
| 1st(1st leg) | PSV Eindhoven | - | Atlético Madrid | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Madrid | - | PSV Eindhoven | 8:7 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 24/02/2016 19:45 | 2nd (2nd leg): 15/03/2016 19:45 | Winner: Atlético Madrid | ||||
| 1st(1st leg) | Dinamo Kiev | - | Manchester City | 1:3 (0:2) | ||
| 2nd (2nd leg) | Manchester City | - | Dinamo Kiev | 0:0 (0:0) | ||
| 1st(1st leg): 24/02/2016 19:45 | 2nd (2nd leg): 15/03/2016 19:45 | Winner: Manchester City | ||||
