1st(1st leg) Spartak Moskva - Fenerbahçe 2:1 (0:0)
2nd (2nd leg) Fenerbahçe - Spartak Moskva 1:1 (0:1)
1st(1st leg): 21/08/2012 17:00 2nd (2nd leg): 29/08/2012 19:45 Winner: Spartak Moskva
1st(1st leg) FC Basel - CFR Cluj 1:2 (1:0)
2nd (2nd leg) CFR Cluj - FC Basel 1:0 (1:0)
1st(1st leg): 21/08/2012 19:45 2nd (2nd leg): 29/08/2012 19:45 Winner: CFR Cluj
1st(1st leg) Helsingborgs IF - Celtic FC 0:2 (0:1)
2nd (2nd leg) Celtic FC - Helsingborgs IF 2:0 (1:0)
1st(1st leg): 21/08/2012 19:45 2nd (2nd leg): 29/08/2012 19:45 Winner: Celtic FC
1st(1st leg) Bor. Mönchengladbach - Dinamo Kiev 1:3 (1:2)
2nd (2nd leg) Dinamo Kiev - Bor. Mönchengladbach 1:2 (0:0)
1st(1st leg): 21/08/2012 19:45 2nd (2nd leg): 29/08/2012 19:45 Winner: Dinamo Kiev
1st(1st leg) FC København - Lille OSC 1:0 (1:0)
2nd (2nd leg) Lille OSC - FC København 2:0 (1:0, 1:0) aet
1st(1st leg): 21/08/2012 19:45 2nd (2nd leg): 29/08/2012 19:45 Winner: Lille OSC
1st(1st leg) BATE Borisov - Ironi Kiryat Shmona 2:0 (1:0)
2nd (2nd leg) Ironi Kiryat Shmona - BATE Borisov 1:1 (0:0)
1st(1st leg): 22/08/2012 19:45 2nd (2nd leg): 28/08/2012 19:45 Winner: BATE Borisov
1st(1st leg) AEL Limassol - RSC Anderlecht 2:1 (1:0)
2nd (2nd leg) RSC Anderlecht - AEL Limassol 2:0 (0:0)
1st(1st leg): 22/08/2012 19:45 2nd (2nd leg): 28/08/2012 19:45 Winner: RSC Anderlecht
1st(1st leg) Dinamo Zagreb - NK Maribor 2:1 (1:1)
2nd (2nd leg) NK Maribor - Dinamo Zagreb 0:1 (0:1)
1st(1st leg): 22/08/2012 19:45 2nd (2nd leg): 28/08/2012 19:45 Winner: Dinamo Zagreb
1st(1st leg) Sporting Braga - Udinese Calcio 1:1 (0:1)
2nd (2nd leg) Udinese Calcio - Sporting Braga 4:5 (1:0, 1:1, 1:1) pso
1st(1st leg): 22/08/2012 19:45 2nd (2nd leg): 28/08/2012 19:45 Winner: Sporting Braga
1st(1st leg) Málaga CF - Panathinaikos 2:0 (2:0)
2nd (2nd leg) Panathinaikos - Málaga CF 0:0 (0:0)
1st(1st leg): 22/08/2012 19:45 2nd (2nd leg): 28/08/2012 19:45 Winner: Málaga CF