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| 1st(1st leg) | Santiago Morning | - | Audax Italiano | 1:3 (1:1) | ||
| 2nd (2nd leg) | Audax Italiano | - | Santiago Morning | 1:1 (1:0) | ||
| 1st(1st leg): 02/09/2015 20:00 | 2nd (2nd leg): 06/09/2015 20:00 | Winner: Audax Italiano | ||||
| 1st(1st leg) | Copiapó | - | Deportes Iquique | 1:1 (0:1) | ||
| 2nd (2nd leg) | Deportes Iquique | - | Copiapó | 1:2 (0:0) | ||
| 1st(1st leg): 02/09/2015 20:00 | 2nd (2nd leg): 06/09/2015 20:00 | Winner: Copiapó | ||||
| 1st(1st leg) | Coquimbo Unido | - | Colo-Colo | 1:1 (0:1) | ||
| 2nd (2nd leg) | Colo-Colo | - | Coquimbo Unido | 3:0 (1:0) | ||
| 1st(1st leg): 02/09/2015 20:00 | 2nd (2nd leg): 09/09/2015 00:00 | Winner: Colo-Colo | ||||
| 1st(1st leg) | Puerto Montt | - | Huachipato | 1:1 (0:0) | ||
| 2nd (2nd leg) | Huachipato | - | Puerto Montt | 5:3 (1:1) | ||
| 1st(1st leg): 02/09/2015 23:00 | 2nd (2nd leg): 06/09/2015 20:00 | Winner: Huachipato | ||||
| 1st(1st leg) | San Luis | - | Universidad de Chile | 3:1 (2:0) | ||
| 2nd (2nd leg) | Universidad de Chile | - | San Luis | 3:0 (0:0) | ||
| 1st(1st leg): 03/09/2015 00:00 | 2nd (2nd leg): 09/09/2015 22:00 | Winner: Universidad de Chile | ||||
| 1st(1st leg) | Cobreloa | - | Universidad Católica | 2:0 (2:0) | ||
| 2nd (2nd leg) | Universidad Católica | - | Cobreloa | 3:4 (1:0, 2:0) pso | ||
| 1st(1st leg): 03/09/2015 20:00 | 2nd (2nd leg): 10/09/2015 00:30 | Winner: Cobreloa | ||||
| 1st(1st leg) | O'Higgins | - | Universidad de Concepción | 2:2 (0:0) | ||
| 2nd (2nd leg) | Universidad de Concepción | - | O'Higgins | 4:1 (2:1, 2:2) pso | ||
| 1st(1st leg): 04/09/2015 00:00 | 2nd (2nd leg): 09/09/2015 20:00 | Winner: Universidad de Concepción | ||||
| 1st(1st leg) | Everton | - | Unión Española | 1:2 (1:1) | ||
| 2nd (2nd leg) | Unión Española | - | Everton | 6:5 (2:1, 2:3) pso | ||
| 1st(1st leg): 04/09/2015 00:00 | 2nd (2nd leg): 06/09/2015 22:00 | Winner: Unión Española | ||||
