1st(1st leg) Santiago Wanderers - Palestino 0:2 (0:2)
2nd (2nd leg) Palestino - Santiago Wanderers 4:3 (2:0)
1st(1st leg): 09/06/2018 17:30 2nd (2nd leg): 16/06/2018 19:00 Winner: Palestino
1st(1st leg) Ñublense - Colo-Colo 2:0 (0:0)
2nd (2nd leg) Colo-Colo - Ñublense 2:1 (1:0)
1st(1st leg): 09/06/2018 20:00 2nd (2nd leg): 22/06/2018 01:00 Winner: Ñublense
1st(1st leg) Puerto Montt - Universidad de Concepción 1:0 (1:0)
2nd (2nd leg) Universidad de Concepción - Puerto Montt 1:2 (1:1)
1st(1st leg): 09/06/2018 23:00 2nd (2nd leg): 16/06/2018 21:00 Winner: Puerto Montt
1st(1st leg) Copiapó - Antofagasta 2:0 (0:0)
2nd (2nd leg) Antofagasta - Copiapó 2:1 (0:1)
1st(1st leg): 10/06/2018 01:00 2nd (2nd leg): 16/06/2018 22:00 Winner: Copiapó
1st(1st leg) La Serena - Universidad de Chile 1:4 (1:1)
2nd (2nd leg) Universidad de Chile - La Serena 2:0 (0:0)
1st(1st leg): 10/06/2018 20:00 2nd (2nd leg): 17/06/2018 00:00 Winner: Universidad de Chile
1st(1st leg) Deportes Valdivia - Deportes Temuco 2:1 (0:1)
2nd (2nd leg) Deportes Temuco - Deportes Valdivia 1:1 (0:1)
1st(1st leg): 10/06/2018 20:30 2nd (2nd leg): 16/06/2018 20:00 Winner: Deportes Valdivia
1st(1st leg) Cobresal - Everton 0:0 (0:0)
2nd (2nd leg) Everton - Cobresal 4:5 (0:0, 1:1) pso
1st(1st leg): 10/06/2018 20:30 2nd (2nd leg): 16/06/2018 01:00 Winner: Cobresal
1st(1st leg) General Velásquez - Unión Española 1:1 (1:1)
2nd (2nd leg) Unión Española - General Velásquez 4:1 (2:0)
1st(1st leg): 10/06/2018 21:00 2nd (2nd leg): 15/06/2018 00:00 Winner: Unión Española
1st(1st leg) San Marcos - Deportes Iquique 4:1 (2:0)
2nd (2nd leg) Deportes Iquique - San Marcos 3:1 (1:0)
1st(1st leg): 10/06/2018 21:00 2nd (2nd leg): 17/06/2018 17:00 Winner: San Marcos
1st(1st leg) Cobreloa - Universidad Católica 1:2 (0:2)
2nd (2nd leg) Universidad Católica - Cobreloa 0:2 (0:2)
1st(1st leg): 10/06/2018 22:30 2nd (2nd leg): 17/06/2018 21:15 Winner: Cobreloa
1st(1st leg) Independiente - Curicó Unido 0:4 (0:1)
2nd (2nd leg) Curicó Unido - Independiente 1:0 (1:0)
1st(1st leg): 12/06/2018 20:30 2nd (2nd leg): 17/06/2018 00:00 Winner: Curicó Unido
1st(1st leg) Coquimbo Unido - Audax Italiano 0:5 (0:1)
2nd (2nd leg) Audax Italiano - Coquimbo Unido 3:1 (1:0)
1st(1st leg): 13/06/2018 01:00 2nd (2nd leg): 18/06/2018 00:00 Winner: Audax Italiano
1st(1st leg) Rangers - Huachipato 1:2 (1:0)
2nd (2nd leg) Huachipato - Rangers 2:0 (1:0)
1st(1st leg): 14/06/2018 00:00 2nd (2nd leg): 17/06/2018 17:00 Winner: Huachipato
1st(1st leg) Barnechea - San Luis 1:1 (1:0)
2nd (2nd leg) San Luis - Barnechea 0:1 (0:0)
1st(1st leg): 14/06/2018 00:30 2nd (2nd leg): 17/06/2018 22:00 Winner: Barnechea
1st(1st leg) CD Magallanes - Unión La Calera 1:1 (0:1)
2nd (2nd leg) Unión La Calera - CD Magallanes 1:0 (0:0)
1st(1st leg): 17/06/2018 20:00 2nd (2nd leg): 21/06/2018 01:00 Winner: Unión La Calera
1st(1st leg) Colchagua - O'Higgins 0:0 (0:0)
2nd (2nd leg) O'Higgins - Colchagua 5:6 (0:0, 0:0) pso
1st(1st leg): 17/06/2018 20:30 2nd (2nd leg): 20/06/2018 23:30 Winner: Colchagua