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| 1st(1st leg) | CS Herediano | - | UANL Tigres | 2:2 (0:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | CS Herediano | 3:1 (0:0) | ||
| 1st(1st leg): 21/02/2018 01:00 | 2nd (2nd leg): 28/02/2018 01:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Colorado Rapids | - | Toronto FC | 0:2 (0:0) | ||
| 2nd (2nd leg) | Toronto FC | - | Colorado Rapids | 0:0 (0:0) | ||
| 1st(1st leg): 21/02/2018 03:00 | 2nd (2nd leg): 28/02/2018 01:00 | Winner: Toronto FC | ||||
| 1st(1st leg) | Tauro FC | - | FC Dallas | 1:0 (0:0) | ||
| 2nd (2nd leg) | FC Dallas | - | Tauro FC | 3:2 (1:2) | ||
| 1st(1st leg): 22/02/2018 01:00 | 2nd (2nd leg): 01/03/2018 01:00 | Winner: Tauro FC | ||||
| 1st(1st leg) | Deportivo Saprissa | - | CF América | 1:5 (0:3) | ||
| 2nd (2nd leg) | CF América | - | Deportivo Saprissa | 1:1 (1:0) | ||
| 1st(1st leg): 22/02/2018 01:00 | 2nd (2nd leg): 01/03/2018 03:00 | Winner: CF América | ||||
| 1st(1st leg) | Motagua | - | Club Tijuana | 0:1 (0:0) | ||
| 2nd (2nd leg) | Club Tijuana | - | Motagua | 1:1 (1:0) | ||
| 1st(1st leg): 22/02/2018 03:00 | 2nd (2nd leg): 28/02/2018 03:00 | Winner: Club Tijuana | ||||
| 1st(1st leg) | Cibao FC | - | Deportivo Guadalajara | 0:2 (0:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Cibao FC | 5:0 (1:0) | ||
| 1st(1st leg): 23/02/2018 01:00 | 2nd (2nd leg): 01/03/2018 01:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Santa Tecla FC | - | Seattle Sounders | 2:1 (0:1) | ||
| 2nd (2nd leg) | Seattle Sounders | - | Santa Tecla FC | 4:0 (0:0) | ||
| 1st(1st leg): 23/02/2018 03:00 | 2nd (2nd leg): 02/03/2018 03:00 | Winner: Seattle Sounders | ||||
| 1st(1st leg) | Olimpia | - | New York RB | 1:1 (0:1) | ||
| 2nd (2nd leg) | New York RB | - | Olimpia | 2:0 (0:0) | ||
| 1st(1st leg): 23/02/2018 03:00 | 2nd (2nd leg): 02/03/2018 01:00 | Winner: New York RB | ||||
