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| 1st(1st leg) | Toronto FC | - | CF América | 3:1 (2:1) | ||
| 2nd (2nd leg) | CF América | - | Toronto FC | 1:1 (0:1) | ||
| 1st(1st leg): 04/04/2018 01:00 | 2nd (2nd leg): 11/04/2018 03:00 | Winner: Toronto FC | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | New York RB | 1:0 (1:0) | ||
| 2nd (2nd leg) | New York RB | - | Deportivo Guadalajara | 0:0 (0:0) | ||
| 1st(1st leg): 05/04/2018 03:00 | 2nd (2nd leg): 11/04/2018 01:00 | Winner: Deportivo Guadalajara | ||||
