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| 1st(1st leg) | CF América | - | Tauro FC | 4:0 (1:0) | ||
| 2nd (2nd leg) | Tauro FC | - | CF América | 1:3 (0:2) | ||
| 1st(1st leg): 07/03/2018 01:00 | 2nd (2nd leg): 15/03/2018 00:00 | Winner: CF América | ||||
| 1st(1st leg) | Club Tijuana | - | New York RB | 0:2 (0:1) | ||
| 2nd (2nd leg) | New York RB | - | Club Tijuana | 3:1 (1:1) | ||
| 1st(1st leg): 07/03/2018 03:00 | 2nd (2nd leg): 14/03/2018 00:00 | Winner: New York RB | ||||
| 1st(1st leg) | Toronto FC | - | UANL Tigres | 2:1 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Toronto FC | 3:2 (0:0) | ||
| 1st(1st leg): 08/03/2018 01:00 | 2nd (2nd leg): 14/03/2018 02:00 | Winner: Toronto FC | ||||
| 1st(1st leg) | Seattle Sounders | - | Deportivo Guadalajara | 1:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Seattle Sounders | 3:0 (0:0) | ||
| 1st(1st leg): 08/03/2018 03:00 | 2nd (2nd leg): 15/03/2018 02:00 | Winner: Deportivo Guadalajara | ||||
