1st(1st leg) Tigre - Deportivo Anzoátegui 2:1 (0:1)
2nd (2nd leg) Deportivo Anzoátegui - Tigre 0:3 (0:1)
1st(1st leg): 22/01/2013 23:15 2nd (2nd leg): 29/01/2013 22:15 Winner: Tigre
1st(1st leg) Club León - Deportes Iquique 1:1 (0:1)
2nd (2nd leg) Deportes Iquique - Club León 4:2 (0:0, 1:1, 1:1) pso
1st(1st leg): 23/01/2013 01:45 2nd (2nd leg): 30/01/2013 01:00 Winner: Deportes Iquique
1st(1st leg) LDU Quito - Grêmio Porto Alegre 1:0 (0:0)
2nd (2nd leg) Grêmio Porto Alegre - LDU Quito 5:4 (0:0, 1:0, 1:0) pso
1st(1st leg): 24/01/2013 00:00 2nd (2nd leg): 31/01/2013 00:00 Winner: Grêmio Porto Alegre
1st(1st leg) São Paulo FC - Club Bolívar 5:0 (3:0)
2nd (2nd leg) Club Bolívar - São Paulo FC 4:3 (1:3)
1st(1st leg): 24/01/2013 00:00 2nd (2nd leg): 31/01/2013 00:00 Winner: São Paulo FC
1st(1st leg) Defensor Sporting - Olimpia Asunción 0:0 (0:0)
2nd (2nd leg) Olimpia Asunción - Defensor Sporting 2:0 (1:0)
1st(1st leg): 24/01/2013 22:00 2nd (2nd leg): 31/01/2013 22:15 Winner: Olimpia Asunción
1st(1st leg) Deportes Tolima - Universidad Cesar Vallejo 1:0 (0:0)
2nd (2nd leg) Universidad Cesar Vallejo - Deportes Tolima 1:1 (1:0)
1st(1st leg): 25/01/2013 00:15 2nd (2nd leg): 01/02/2013 00:45 Winner: Deportes Tolima