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| 1st(1st leg) | Huracán | - | Atlético Nacional | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Huracán | 4:2 (1:1) | ||
| 1st(1st leg): 26/04/2016 23:30 | 2nd (2nd leg): 04/05/2016 01:45 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | Deportivo Táchira | - | Pumas UNAM | 1:0 (0:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | Deportivo Táchira | 2:0 (1:0) | ||
| 1st(1st leg): 27/04/2016 01:45 | 2nd (2nd leg): 04/05/2016 03:45 | Winner: Pumas UNAM | ||||
| 1st(1st leg) | Racing Club | - | Atlético Mineiro | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Racing Club | 2:1 (1:1) | ||
| 1st(1st leg): 27/04/2016 23:30 | 2nd (2nd leg): 05/05/2016 01:45 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Nacional | - | Corinthians SP | 0:0 (0:0) | ||
| 2nd (2nd leg) | Corinthians SP | - | Nacional | 2:2 (1:1) | ||
| 1st(1st leg): 28/04/2016 01:45 | 2nd (2nd leg): 05/05/2016 01:45 | Winner: Nacional | ||||
| 1st(1st leg) | Grêmio Porto Alegre | - | Rosario Central | 0:1 (0:1) | ||
| 2nd (2nd leg) | Rosario Central | - | Grêmio Porto Alegre | 3:0 (2:0) | ||
| 1st(1st leg): 28/04/2016 01:45 | 2nd (2nd leg): 05/05/2016 23:15 | Winner: Rosario Central | ||||
| 1st(1st leg) | Independiente del Valle | - | River Plate | 2:0 (0:0) | ||
| 2nd (2nd leg) | River Plate | - | Independiente del Valle | 1:0 (0:0) | ||
| 1st(1st leg): 28/04/2016 23:30 | 2nd (2nd leg): 04/05/2016 23:15 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | São Paulo FC | - | Deportivo Toluca | 4:0 (2:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | São Paulo FC | 3:1 (1:0) | ||
| 1st(1st leg): 29/04/2016 01:45 | 2nd (2nd leg): 04/05/2016 23:15 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Cerro Porteño | - | Boca Juniors | 1:2 (0:1) | ||
| 2nd (2nd leg) | Boca Juniors | - | Cerro Porteño | 3:1 (1:1) | ||
| 1st(1st leg): 29/04/2016 01:45 | 2nd (2nd leg): 06/05/2016 01:45 | Winner: Boca Juniors | ||||
