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| 1st(1st leg) | Sportivo Luqueño | - | Santa Fe | 1:1 (1:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Sportivo Luqueño | 0:0 (0:0) | ||
| 1st(1st leg): 04/11/2015 23:45 | 2nd (2nd leg): 26/11/2015 00:00 | Winner: Santa Fe | ||||
| 1st(1st leg) | River Plate | - | Huracán | 0:1 (0:1) | ||
| 2nd (2nd leg) | Huracán | - | River Plate | 2:2 (2:0) | ||
| 1st(1st leg): 05/11/2015 23:45 | 2nd (2nd leg): 26/11/2015 23:45 | Winner: Huracán | ||||
