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| 1st(1st leg) | Cerro Porteño | - | Atlético Nacional | 1:1 (1:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Cerro Porteño | 0:0 (0:0) | ||
| 1st(1st leg): 01/11/2016 23:45 | 2nd (2nd leg): 25/11/2016 00:45 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | San Lorenzo | - | Chapecoense | 1:1 (1:0) | ||
| 2nd (2nd leg) | Chapecoense | - | San Lorenzo | 0:0 (0:0) | ||
| 1st(1st leg): 02/11/2016 23:45 | 2nd (2nd leg): 23/11/2016 23:45 | Winner: Chapecoense | ||||
