1st(1st leg) Slavia Sofia - Feyenoord 3:2 (1:1)
2nd (2nd leg) Feyenoord - Slavia Sofia 4:0 (1:0)
1st(1st leg): 04/03/1981 2nd (2nd leg): 18/03/1981 Winner: Feyenoord
1st(1st leg) FC Carl Zeiss Jena - Newport County 2:2 (1:1)
2nd (2nd leg) Newport County - FC Carl Zeiss Jena 0:1 (0:1)
1st(1st leg): 04/03/1981 2nd (2nd leg): 18/03/1981 Winner: FC Carl Zeiss Jena
1st(1st leg) Fortuna Düsseldorf - SL Benfica 2:2 (2:1)
2nd (2nd leg) SL Benfica - Fortuna Düsseldorf 1:0 (0:0)
1st(1st leg): 04/03/1981 2nd (2nd leg): 18/03/1981 Winner: SL Benfica
1st(1st leg) West Ham United - Dinamo Tbilisi 1:4 (0:2)
2nd (2nd leg) Dinamo Tbilisi - West Ham United 0:1 (0:0)
1st(1st leg): 04/03/1981 2nd (2nd leg): 18/03/1981 Winner: Dinamo Tbilisi