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| 1st(1st leg) | FC Cartagena | - | Sevilla FC | 0:3 (0:2) | ||
| 2nd (2nd leg) | Sevilla FC | - | FC Cartagena | 4:0 (3:0) | ||
| 1st(1st leg): 24/10/2017 18:30 | 2nd (2nd leg): 29/11/2017 18:30 | Winner: Sevilla FC | ||||
| 1st(1st leg) | CD Numancia | - | Málaga CF | 2:1 (0:1) | ||
| 2nd (2nd leg) | Málaga CF | - | CD Numancia | 1:1 (1:0) | ||
| 1st(1st leg): 24/10/2017 18:30 | 2nd (2nd leg): 28/11/2017 18:30 | Winner: CD Numancia | ||||
| 1st(1st leg) | Real Zaragoza | - | Valencia CF | 0:2 (0:0) | ||
| 2nd (2nd leg) | Valencia CF | - | Real Zaragoza | 4:1 (1:0) | ||
| 1st(1st leg): 24/10/2017 19:30 | 2nd (2nd leg): 30/11/2017 20:30 | Winner: Valencia CF | ||||
| 1st(1st leg) | Getafe CF | - | CD Alavés | 0:1 (0:0) | ||
| 2nd (2nd leg) | CD Alavés | - | Getafe CF | 3:0 (2:0) | ||
| 1st(1st leg): 24/10/2017 19:30 | 2nd (2nd leg): 30/11/2017 18:00 | Winner: CD Alavés | ||||
| 1st(1st leg) | Real Murcia | - | FC Barcelona | 0:3 (0:1) | ||
| 2nd (2nd leg) | FC Barcelona | - | Real Murcia | 5:0 (1:0) | ||
| 1st(1st leg): 24/10/2017 20:30 | 2nd (2nd leg): 29/11/2017 18:30 | Winner: FC Barcelona | ||||
| 1st(1st leg) | Cádiz CF | - | Real Betis | 1:2 (1:1) | ||
| 2nd (2nd leg) | Real Betis | - | Cádiz CF | 3:5 (2:4) | ||
| 1st(1st leg): 24/10/2017 20:30 | 2nd (2nd leg): 30/11/2017 20:30 | Winner: Cádiz CF | ||||
| 1st(1st leg) | SD Formentera | - | Athletic Bilbao | 1:1 (0:0) | ||
| 2nd (2nd leg) | Athletic Bilbao | - | SD Formentera | 0:1 (0:0) | ||
| 1st(1st leg): 25/10/2017 18:00 | 2nd (2nd leg): 29/11/2017 20:30 | Winner: SD Formentera | ||||
| 1st(1st leg) | SD Ponferradina | - | Villarreal CF | 1:0 (1:0) | ||
| 2nd (2nd leg) | Villarreal CF | - | SD Ponferradina | 3:0 (0:0) | ||
| 1st(1st leg): 25/10/2017 19:30 | 2nd (2nd leg): 30/11/2017 18:30 | Winner: Villarreal CF | ||||
| 1st(1st leg) | Real Valladolid | - | CD Leganés | 1:2 (0:0) | ||
| 2nd (2nd leg) | CD Leganés | - | Real Valladolid | 1:0 (1:0) | ||
| 1st(1st leg): 25/10/2017 19:30 | 2nd (2nd leg): 28/11/2017 18:30 | Winner: CD Leganés | ||||
| 1st(1st leg) | Elche CF | - | Atlético Madrid | 1:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Madrid | - | Elche CF | 3:0 (2:0) | ||
| 1st(1st leg): 25/10/2017 20:30 | 2nd (2nd leg): 29/11/2017 20:30 | Winner: Atlético Madrid | ||||
| 1st(1st leg) | SD Eibar | - | RC Celta | 1:2 (1:2) | ||
| 2nd (2nd leg) | RC Celta | - | SD Eibar | 1:0 (0:0) | ||
| 1st(1st leg): 25/10/2017 20:30 | 2nd (2nd leg): 28/11/2017 20:30 | Winner: RC Celta | ||||
| 1st(1st leg) | Lleida Esportiu | - | Real Sociedad | 0:1 (0:1) | ||
| 2nd (2nd leg) | Real Sociedad | - | Lleida Esportiu | 2:3 (2:0) | ||
| 1st(1st leg): 26/10/2017 18:30 | 2nd (2nd leg): 29/11/2017 18:30 | Winner: Lleida Esportiu | ||||
| 1st(1st leg) | Deportivo La Coruña | - | UD Las Palmas | 1:4 (0:2) | ||
| 2nd (2nd leg) | UD Las Palmas | - | Deportivo La Coruña | 2:3 (0:1) | ||
| 1st(1st leg): 26/10/2017 19:30 | 2nd (2nd leg): 29/11/2017 20:30 | Winner: UD Las Palmas | ||||
| 1st(1st leg) | Girona FC | - | Levante UD | 0:2 (0:1) | ||
| 2nd (2nd leg) | Levante UD | - | Girona FC | 1:1 (0:1) | ||
| 1st(1st leg): 26/10/2017 19:30 | 2nd (2nd leg): 28/11/2017 20:30 | Winner: Levante UD | ||||
| 1st(1st leg) | CF Fuenlabrada | - | Real Madrid | 0:2 (0:0) | ||
| 2nd (2nd leg) | Real Madrid | - | CF Fuenlabrada | 2:2 (0:1) | ||
| 1st(1st leg): 26/10/2017 20:30 | 2nd (2nd leg): 28/11/2017 20:30 | Winner: Real Madrid | ||||
| 1st(1st leg) | CD Tenerife | - | Espanyol Barcelona | 0:0 (0:0) | ||
| 2nd (2nd leg) | Espanyol Barcelona | - | CD Tenerife | 3:2 (1:1) | ||
| 1st(1st leg): 26/10/2017 20:30 | 2nd (2nd leg): 30/11/2017 18:30 | Winner: Espanyol Barcelona | ||||
