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| 1st(1st leg) | Cafetaleros de Tapachula | - | Dorados de Sinaloa | 3:2 | ||
| 2nd (2nd leg) | Dorados de Sinaloa | - | Cafetaleros de Tapachula | 0:2 | ||
| 1st(1st leg): 19/04/2018 02:30 | 2nd (2nd leg): 22/04/2018 03:00 | Winner: Cafetaleros de Tapachula | ||||
| 1st(1st leg) | Alebrijes de Oaxaca | - | Leones Negros | 2:2 | ||
| 2nd (2nd leg) | Leones Negros | - | Alebrijes de Oaxaca | 1:1 | ||
| 1st(1st leg): 20/04/2018 02:00 | 2nd (2nd leg): 22/04/2018 18:00 | Winner: Leones Negros | ||||
