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| 1st(1st leg) | UANL Tigres | - | CF Monterrey | 1:3 (1:2) | ||
| 2nd (2nd leg) | CF Monterrey | - | UANL Tigres | 1:2 (0:2) | ||
| 1st(1st leg): 12/05/2016 01:00 | 2nd (2nd leg): 15/05/2016 01:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Monarcas Morelia | - | Club León | 1:1 (0:0) | ||
| 2nd (2nd leg) | Club León | - | Monarcas Morelia | 4:1 (1:0) | ||
| 1st(1st leg): 12/05/2016 03:00 | 2nd (2nd leg): 15/05/2016 03:06 | Winner: Club León | ||||
| 1st(1st leg) | Santos Laguna | - | CF Pachuca | 1:1 (0:1) | ||
| 2nd (2nd leg) | CF Pachuca | - | Santos Laguna | 3:2 (1:1) | ||
| 1st(1st leg): 13/05/2016 01:00 | 2nd (2nd leg): 16/05/2016 02:06 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | CF América | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF América | - | Deportivo Guadalajara | 2:1 (1:1) | ||
| 1st(1st leg): 13/05/2016 03:00 | 2nd (2nd leg): 16/05/2016 00:00 | Winner: CF América | ||||
