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| 1st(1st leg) | Club León | - | Club Tijuana | 3:0 (2:0) | ||
| 2nd (2nd leg) | Club Tijuana | - | Club León | 3:2 (3:0) | ||
| 1st(1st leg): 24/11/2016 01:30 | 2nd (2nd leg): 27/11/2016 03:00 | Winner: Club León | ||||
| 1st(1st leg) | Pumas UNAM | - | UANL Tigres | 2:2 (1:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | Pumas UNAM | 5:0 (2:0) | ||
| 1st(1st leg): 24/11/2016 03:30 | 2nd (2nd leg): 27/11/2016 01:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Club Necaxa | - | CF Pachuca | 2:1 (1:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Club Necaxa | 0:0 (0:0) | ||
| 1st(1st leg): 25/11/2016 01:30 | 2nd (2nd leg): 28/11/2016 02:06 | Winner: Club Necaxa | ||||
| 1st(1st leg) | CF América | - | Deportivo Guadalajara | 1:1 (1:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF América | 0:1 (0:0) | ||
| 1st(1st leg): 25/11/2016 03:30 | 2nd (2nd leg): 28/11/2016 00:06 | Winner: CF América | ||||
