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| 1st(1st leg) | Santos Laguna | - | CF América | 4:1 (2:1) | ||
| 2nd (2nd leg) | CF América | - | Santos Laguna | 2:2 (2:1) | ||
| 1st(1st leg): 11/05/2018 01:30 | 2nd (2nd leg): 14/05/2018 01:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | Club Tijuana | - | Deportivo Toluca | 2:1 (1:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Club Tijuana | 4:1 (2:0) | ||
| 1st(1st leg): 11/05/2018 03:30 | 2nd (2nd leg): 13/05/2018 18:00 | Winner: Deportivo Toluca | ||||
