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| 11/09/2012 | 14:30 | ACS Bacău | - | FC Botoşani | 2:3 (0:0, 0:0, 0:0) pso | |
| 14:30 | FC Zagon | - | Rapid CFR Suceava | 4:1 | ||
| 14:30 | Conpet Ploieşti | - | CF Brăila | 0:5 (0:2) | ||
| 14:30 | CS Baloteşti | - | Farul Constanța | 0:1 (0:0, 0:0) aet | ||
| 14:30 | CS Afumaţi | - | Delta Tulcea | 0:3 | ||
| 14:30 | ACS Berceni | - | Săgeata Năvodari | 1:0 (0:0) | ||
| 14:30 | FC Caracal | - | Dinamo Bucureşti II | 2:1 | ||
| 14:30 | CSM Alexandria | - | Sportul Studenţesc | 1:3 | ||
| 14:30 | AS Voinţa Lupac | - | Damila Măciuca | 0:3 | ||
| 14:30 | Pandurii Târgu Jiu II | - | CS Mioveni | 1:2 | ||
| 14:30 | FC Cisnădie | - | Voinţa Sibiu | 3:4 pso | ||
| 14:30 | Şoimii Pâncota | - | UTA Arad | 1:0 (1:0) | ||
| 14:30 | Olimpia Satu Mare | - | FC Bihor Oradea | 3:2 (2:1, 2:2) aet | ||
| 14:30 | Seso Câmpia Turzii | - | FCM Târgu Mureş | 0:1 (0:1) |
