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| 25/09/2012 | 14:00 | Ceahlăul Piatra Neamt | - | Gloria Bistrița (old) | 4:0 (2:0) | |
| 14:30 | Şoimii Pâncota | - | Concordia Chiajna | 2:3 (0:2) | ||
| 17:00 | Dinamo Bucureşti | - | Voinţa Sibiu | 2:1 (0:0, 1:1) aet | ||
| 19:30 | Petrolul Ploieşti | - | Damila Măciuca | 2:0 (1:0) | ||
| 26/09/2012 | 14:00 | Sportul Studenţesc | - | Oţelul Galaţi | 0:1 (0:1) | |
| 14:30 | CS Turnu Severin | - | CS Mioveni | 2:1 (1:0) | ||
| 14:30 | Pandurii Târgu Jiu | - | FC Zagon | 7:1 (6:0) | ||
| 14:30 | Delta Tulcea | - | Universitatea Cluj | 2:1 (1:0) | ||
| 14:30 | Gaz Metan Mediaş | - | FC Caracal | 2:1 (0:0) | ||
| 14:30 | FC Vaslui | - | FC Botoşani | 0:1 (0:0) | ||
| 17:00 | ACS Berceni | - | CFR Cluj | 0:2 (0:0) | ||
| 17:00 | FC Brașov | - | Farul Constanța | 1:0 (1:0) | ||
| 27/09/2012 | 14:00 | CF Brăila | - | FC Viitorul Constanța | 6:5 (0:0, 0:0, 0:0) pso | |
| 15:00 | CSM Studențesc Iași | - | Astra Giurgiu | 1:4 (1:0) | ||
| 17:00 | Rapid Bucureşti | - | Olimpia Satu Mare | 6:0 (3:0) | ||
| 19:30 | FC Steaua Bucureşti | - | FCM Târgu Mureş | 3:1 (1:1) |
