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| 1st(1st leg) | Columbus Crew | - | New York RB | 2:0 (1:0) | ||
| 2nd (2nd leg) | New York RB | - | Columbus Crew | 1:0 (0:0) | ||
| 1st(1st leg): 22/11/2015 22:00 | 2nd (2nd leg): 30/11/2015 00:30 | Winner: Columbus Crew | ||||
| 1st(1st leg) | Portland Timbers | - | FC Dallas | 3:1 (1:0) | ||
| 2nd (2nd leg) | FC Dallas | - | Portland Timbers | 2:2 (0:0) | ||
| 1st(1st leg): 23/11/2015 00:30 | 2nd (2nd leg): 29/11/2015 22:00 | Winner: Portland Timbers | ||||
