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| 1st(1st leg) | Aragua FC | - | Carabobo FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Carabobo FC | - | Aragua FC | 2:0 (1:0) | ||
| 1st(1st leg): 26/05/2018 22:00 | 2nd (2nd leg): 30/05/2018 22:00 | Winner: Carabobo FC | ||||
| 1st(1st leg) | Deportivo La Guaira | - | Mineros de Guayana | 0:0 (0:0) | ||
| 2nd (2nd leg) | Mineros de Guayana | - | Deportivo La Guaira | 2:0 (0:0) | ||
| 1st(1st leg): 27/05/2018 00:30 | 2nd (2nd leg): 31/05/2018 00:30 | Winner: Mineros de Guayana | ||||
| 1st(1st leg) | Estudiantes de Mérida | - | Zamora FC | 1:3 (0:1) | ||
| 2nd (2nd leg) | Zamora FC | - | Estudiantes de Mérida | 3:1 (2:1) | ||
| 1st(1st leg): 27/05/2018 22:00 | 2nd (2nd leg): 31/05/2018 22:00 | Winner: Zamora FC | ||||
| 1st(1st leg) | Deportivo Lara | - | Caracas FC | 1:3 (1:2) | ||
| 2nd (2nd leg) | Caracas FC | - | Deportivo Lara | 2:0 (1:0) | ||
| 1st(1st leg): 28/05/2018 00:50 | 2nd (2nd leg): 01/06/2018 00:30 | Winner: Caracas FC | ||||
