1st(1st leg) Inter Baku - Partizan 1:1 (0:1)
2nd (2nd leg) Partizan - Inter Baku 2:0 (0:0)
1st(1st leg): 29/07/2008 15:00 2nd (2nd leg): 06/08/2008 19:45 Winner: Partizan
1st(1st leg) SK Brann - FK Ventspils 1:0 (0:0)
2nd (2nd leg) FK Ventspils - SK Brann 2:1 (2:0)
1st(1st leg): 29/07/2008 19:45 2nd (2nd leg): 05/08/2008 16:00 Winner: SK Brann
1st(1st leg) Drogheda United - Dinamo Kiev 1:2 (0:1)
2nd (2nd leg) Dinamo Kiev - Drogheda United 2:2 (1:1)
1st(1st leg): 29/07/2008 19:45 2nd (2nd leg): 06/08/2008 17:00 Winner: Dinamo Kiev
1st(1st leg) Tampere United - FC Artmedia Petržalka 1:3 (1:2)
2nd (2nd leg) FC Artmedia Petržalka - Tampere United 4:2 (3:0)
1st(1st leg): 30/07/2008 17:00 2nd (2nd leg): 06/08/2008 19:15 Winner: FC Artmedia Petržalka
1st(1st leg) FC Sheriff - AC Sparta Praha 0:1 (0:0)
2nd (2nd leg) AC Sparta Praha - FC Sheriff 2:0 (1:0)
1st(1st leg): 30/07/2008 18:00 2nd (2nd leg): 06/08/2008 19:15 Winner: AC Sparta Praha
1st(1st leg) Beitar Jerusalem - Wisła Kraków 2:1 (0:1)
2nd (2nd leg) Wisła Kraków - Beitar Jerusalem 5:0 (3:0)
1st(1st leg): 30/07/2008 19:00 2nd (2nd leg): 06/08/2008 19:45 Winner: Wisła Kraków
1st(1st leg) Fenerbahçe - MTK Budapest 2:0 (1:0)
2nd (2nd leg) MTK Budapest - Fenerbahçe 0:5 (0:1)
1st(1st leg): 30/07/2008 19:00 2nd (2nd leg): 06/08/2008 19:45 Winner: Fenerbahçe
1st(1st leg) Aalborg BK - FK Modriča 5:0 (3:0)
2nd (2nd leg) FK Modriča - Aalborg BK 1:2 (0:1)
1st(1st leg): 30/07/2008 19:00 2nd (2nd leg): 06/08/2008 19:00 Winner: Aalborg BK
1st(1st leg) IFK Göteborg - FC Basel 1:1 (1:1)
2nd (2nd leg) FC Basel - IFK Göteborg 4:2 (1:1)
1st(1st leg): 30/07/2008 19:15 2nd (2nd leg): 06/08/2008 19:15 Winner: FC Basel
1st(1st leg) Anorthosis Famagusta - Rapid Wien 3:0 (1:0)
2nd (2nd leg) Rapid Wien - Anorthosis Famagusta 3:1 (1:1)
1st(1st leg): 30/07/2008 19:30 2nd (2nd leg): 06/08/2008 18:30 Winner: Anorthosis Famagusta
1st(1st leg) RSC Anderlecht - BATE Borisov 1:2 (0:0)
2nd (2nd leg) BATE Borisov - RSC Anderlecht 2:2 (1:1)
1st(1st leg): 30/07/2008 19:30 2nd (2nd leg): 06/08/2008 17:00 Winner: BATE Borisov
1st(1st leg) Rangers FC - FBK Kaunas 0:0 (0:0)
2nd (2nd leg) FBK Kaunas - Rangers FC 2:1 (1:1)
1st(1st leg): 30/07/2008 19:45 2nd (2nd leg): 05/08/2008 18:05 Winner: FBK Kaunas
1st(1st leg) NK Domžale - Dinamo Zagreb 0:3 (0:3)
2nd (2nd leg) Dinamo Zagreb - NK Domžale 3:2 (1:1)
1st(1st leg): 30/07/2008 19:45 2nd (2nd leg): 06/08/2008 19:45 Winner: Dinamo Zagreb
1st(1st leg) Panathinaikos - Dinamo Tbilisi 3:0 (2:0)
2nd (2nd leg) Dinamo Tbilisi - Panathinaikos 0:0 (0:0)
1st(1st leg): 30/07/2008 19:45 2nd (2nd leg): 06/08/2008 17:00 Winner: Panathinaikos