1. Round
07/04/2001 D.C. United - Kansas City Wizards 3:2 (1:2)
Columbus Crew - Chicago Fire 1:1 (0:1, 1:1) aet
Dallas Burn - Tampa Bay Mutiny 2:4 (2:2)
Los Angeles Galaxy - San Jose Earthquakes 2:3 (0:3)
MetroStars - New England Revolution 2:1 (0:0, 1:1) aet
Miami Fusion - Colorado Rapids 2:1 (0:0)
14/04/2001 Colorado Rapids - MetroStars 1:1 (0:1, 1:1) aet
Tampa Bay Mutiny - Columbus Crew 1:2 (0:1)
New England Revolution - Miami Fusion 0:1 (0:0)
Chicago Fire - D.C. United 2:0 (0:0)
Kansas City Wizards - Los Angeles Galaxy 2:1 (1:0)
San Jose Earthquakes - Dallas Burn 0:1 (0:1)
18/04/2001 Kansas City Wizards - Miami Fusion 2:1 (0:0)
21/04/2001 Miami Fusion - San Jose Earthquakes 2:1 (2:0)
Columbus Crew - Kansas City Wizards 0:3 (0:1)
D.C. United - New England Revolution 2:1 (1:0)
Dallas Burn - Chicago Fire 3:2 (0:1, 2:2) aet
MetroStars - Tampa Bay Mutiny 1:3 (1:0)
Los Angeles Galaxy - Colorado Rapids 1:0 (1:0)
28/04/2001 Kansas City Wizards - San Jose Earthquakes 0:0 (0:0, 0:0) aet
MetroStars - Dallas Burn 3:2 (2:0)
Tampa Bay Mutiny - Chicago Fire 0:1 (0:1)
Miami Fusion - New England Revolution 1:0 (0:0)
Colorado Rapids - Los Angeles Galaxy 2:3 (1:2)
2. Round
02/05/2001 MetroStars - Kansas City Wizards 4:1 (2:1)
05/05/2001 Dallas Burn - Colorado Rapids 0:1 (0:0)
Los Angeles Galaxy - Kansas City Wizards 2:1 (1:1)
San Jose Earthquakes - New England Revolution 3:2 (1:0)
MetroStars - D.C. United 3:2 (0:1)
Columbus Crew - Miami Fusion 0:0 (0:0, 0:0) aet
Chicago Fire - Tampa Bay Mutiny 2:0 (0:0)
09/05/2001 D.C. United - New England Revolution 5:0 (4:0)
Tampa Bay Mutiny - Los Angeles Galaxy 4:4 (3:2, 4:4) aet
12/05/2001 Dallas Burn - Columbus Crew 4:0 (1:0)
Colorado Rapids - Tampa Bay Mutiny 2:1 (0:0)
D.C. United - San Jose Earthquakes 2:3 (0:1)
New England Revolution - Chicago Fire 2:1 (1:0)
MetroStars - Los Angeles Galaxy 2:0 (0:0)
16/05/2001 MetroStars - Colorado Rapids 1:0 (1:0)
New England Revolution - Columbus Crew 2:1 (0:0)
19/05/2001 Los Angeles Galaxy - Dallas Burn 0:0 (0:0, 0:0) aet
Miami Fusion - Tampa Bay Mutiny 3:1 (2:1)
Colorado Rapids - New England Revolution 0:1 (0:0)
Columbus Crew - D.C. United 2:1 (1:0, 1:1) aet
Chicago Fire - Kansas City Wizards 2:0 (2:0)
San Jose Earthquakes - MetroStars 2:0 (1:0)
23/05/2001 Dallas Burn - San Jose Earthquakes 0:2 (0:1)
Colorado Rapids - Miami Fusion 0:1 (0:0)
24/05/2001 Kansas City Wizards - MetroStars 1:0 (0:0, 0:0) aet
26/05/2001 Tampa Bay Mutiny - Miami Fusion 0:4 (0:2)
Chicago Fire - San Jose Earthquakes 1:1 (0:0, 1:1) aet
Los Angeles Galaxy - New England Revolution 2:0 (0:0)
Columbus Crew - Colorado Rapids 3:3 (1:2, 3:3) aet
30/05/2001 Chicago Fire - Los Angeles Galaxy 3:4 (2:2)
San Jose Earthquakes - Colorado Rapids 1:1 (1:0, 1:1) aet
Miami Fusion - D.C. United 2:1 (1:0)
3. Round
02/06/2001 Colorado Rapids - San Jose Earthquakes 1:2 (1:2)
Tampa Bay Mutiny - Kansas City Wizards 1:2 (1:1)
Dallas Burn - Miami Fusion 2:6 (1:3)
D.C. United - Chicago Fire 1:2 (1:0)
Columbus Crew - Los Angeles Galaxy 1:1 (0:0, 1:1) aet
03/06/2001 New England Revolution - MetroStars 1:1 (0:1, 1:1) aet
06/06/2001 Tampa Bay Mutiny - Dallas Burn 0:1 (0:1)
09/06/2001 New England Revolution - Tampa Bay Mutiny 3:0 (2:0)
Miami Fusion - Kansas City Wizards 5:1 (1:0)
San Jose Earthquakes - Los Angeles Galaxy 3:1 (1:0)
Chicago Fire - Columbus Crew 1:0 (1:0)
Dallas Burn - D.C. United 3:0 (2:0)
13/06/2001 D.C. United - MetroStars 2:1 (0:1)
Los Angeles Galaxy - Kansas City Wizards 4:0 (2:0)
16/06/2001 Kansas City Wizards - D.C. United 0:3 (0:0)
Colorado Rapids - Dallas Burn 3:6 (3:3)
MetroStars - San Jose Earthquakes 0:0 (0:0, 0:0) aet
Columbus Crew - Tampa Bay Mutiny 6:1 (2:0)
Miami Fusion - Los Angeles Galaxy 3:3 (1:3, 3:3) aet
20/06/2001 New England Revolution - Colorado Rapids 3:3 (1:2, 3:3) aet
23/06/2001 Tampa Bay Mutiny - D.C. United 3:2 (3:0)
San Jose Earthquakes - Kansas City Wizards 2:0 (1:0)
Dallas Burn - Columbus Crew 1:2 (1:1)
Los Angeles Galaxy - MetroStars 2:0 (0:0)
Chicago Fire - New England Revolution 1:1 (0:0, 1:1) aet
30/06/2001 Kansas City Wizards - Tampa Bay Mutiny 3:0 (2:0)
Miami Fusion - Columbus Crew 4:3 (3:1)
Dallas Burn - Los Angeles Galaxy 0:0 (0:0, 0:0) aet
D.C. United - Colorado Rapids 1:1 (0:1, 1:1) aet
Chicago Fire - MetroStars 3:1 (3:0)
4. Round
04/07/2001 San Jose Earthquakes - Miami Fusion 1:1 (0:1, 1:1) aet
Kansas City Wizards - Chicago Fire 0:7 (0:3)
Colorado Rapids - D.C. United 3:1 (1:0)
Dallas Burn - New England Revolution 1:1 (0:1, 1:1) aet
Tampa Bay Mutiny - MetroStars 1:2 (1:0, 1:1) aet
Los Angeles Galaxy - Columbus Crew 0:2 (0:0)
07/07/2001 Colorado Rapids - San Jose Earthquakes 3:1 (2:0)
Columbus Crew - Dallas Burn 2:2 (0:0, 2:2) aet
New England Revolution - Kansas City Wizards 1:2 (0:0)
Miami Fusion - MetroStars 0:3 (0:0)
Tampa Bay Mutiny - Chicago Fire 2:3 (0:0)
D.C. United - Los Angeles Galaxy 0:3 (0:0)
14/07/2001 Chicago Fire - Colorado Rapids 1:0 (0:0, 0:0) aet
Kansas City Wizards - Dallas Burn 3:2 (0:1)
New England Revolution - D.C. United 1:3 (0:1)
San Jose Earthquakes - Tampa Bay Mutiny 2:1 (1:0, 1:1) aet
Los Angeles Galaxy - Miami Fusion 3:0 (1:0)
17/07/2001 New England Revolution - Los Angeles Galaxy 3:2 (2:2)
18/07/2001 Columbus Crew - MetroStars 2:1 (0:0)
San Jose Earthquakes - D.C. United 4:0 (1:0)
Miami Fusion - Chicago Fire 2:1 (2:0)
Colorado Rapids - Kansas City Wizards 0:0 (0:0, 0:0) aet
Dallas Burn - Tampa Bay Mutiny 3:0 (1:0)
21/07/2001 Columbus Crew - San Jose Earthquakes 2:1 (1:1)
Tampa Bay Mutiny - Colorado Rapids 1:2 (1:2)
Miami Fusion - New England Revolution 1:1 (1:0, 1:1) aet
MetroStars - D.C. United 2:1 (1:0)
Chicago Fire - Dallas Burn 2:1 (0:1, 1:1) aet
29/07/2001 Kansas City Wizards - New England Revolution 2:0 (1:0)
5. Round
01/08/2001 Columbus Crew - Chicago Fire 3:0 (0:0)
D.C. United - Miami Fusion 2:2 (2:0, 2:2) aet
04/08/2001 New England Revolution - Dallas Burn 5:1 (1:0)
MetroStars - Miami Fusion 2:1 (1:0)
Kansas City Wizards - Columbus Crew 1:3 (0:2)
Tampa Bay Mutiny - San Jose Earthquakes 2:0 (2:0)
Colorado Rapids - Chicago Fire 1:1 (1:1, 1:1) aet
08/08/2001 New England Revolution - San Jose Earthquakes 1:5 (1:2)
11/08/2001 New England Revolution - Miami Fusion 1:4 (1:3)
San Jose Earthquakes - Columbus Crew 2:2 (2:1, 2:2) aet
Chicago Fire - Tampa Bay Mutiny 3:1 (1:1)
Los Angeles Galaxy - D.C. United 1:0 (0:0)
Dallas Burn - MetroStars 3:0 (2:0)
12/08/2001 Colorado Rapids - Kansas City Wizards 2:2 (1:0, 2:2) aet
15/08/2001 D.C. United - MetroStars 1:2 (0:2)
Kansas City Wizards - Los Angeles Galaxy 1:2 (0:1, 1:1) aet
Chicago Fire - Miami Fusion 1:2 (1:2)
Columbus Crew - Dallas Burn 3:0 (1:0)
18/08/2001 New England Revolution - D.C. United 2:1 (2:1)
Los Angeles Galaxy - Tampa Bay Mutiny 5:1 (3:1)
San Jose Earthquakes - Chicago Fire 0:1 (0:1)
Miami Fusion - Dallas Burn 4:2 (1:1)
19/08/2001 MetroStars - Columbus Crew 0:1 (0:1)
Kansas City Wizards - Colorado Rapids 3:2 (2:0)
25/08/2001 Miami Fusion - MetroStars 2:3 (1:0)
Dallas Burn - Kansas City Wizards 3:0 (2:0)
San Jose Earthquakes - Colorado Rapids 5:2 (4:0)
D.C. United - Columbus Crew 2:1 (0:1)
Los Angeles Galaxy - Chicago Fire 1:3 (0:1)
26/08/2001 Tampa Bay Mutiny - New England Revolution 0:0 (0:0, 0:0) aet
29/08/2001 Chicago Fire - Columbus Crew 2:1 (0:1)
Tampa Bay Mutiny - Dallas Burn 2:3 (1:1, 2:2) aet
6. Round
01/09/2001 San Jose Earthquakes - Kansas City Wizards 3:0 (0:0)
Los Angeles Galaxy - Colorado Rapids 3:2 (1:1, 2:2) aet
D.C. United - Tampa Bay Mutiny 5:1 (2:0)
Columbus Crew - New England Revolution 4:1 (0:1)
MetroStars - Chicago Fire 0:1 (0:0, 0:0) aet
07/09/2001 MetroStars - New England Revolution 3:1 (3:1)
08/09/2001 Kansas City Wizards - San Jose Earthquakes 1:0 (1:0)
Miami Fusion - D.C. United 3:1 (2:0)
Chicago Fire - Dallas Burn 2:2 (0:0, 2:2) aet
Colorado Rapids - Los Angeles Galaxy 0:2 (0:1)
09/09/2001 Tampa Bay Mutiny - Columbus Crew 1:2 (1:2)