| 1. Round | 24/07/2021 | Pau FC | - | AS Nancy Lorraine | 2:1 | ||||
| 10. Round | 24/09/2021 | AS Nancy Lorraine | - | Amiens SC | 1:1 | ||||
| 11. Round | 02/10/2021 | Paris FC | - | AS Nancy Lorraine | 1:1 | ||||
| 23. Round | 05/02/2022 | AS Nancy Lorraine | - | SM Caen | 1:1 | ||||
| 24. Round | 12/02/2022 | AJ Auxerre | - | AS Nancy Lorraine | 1:1 | ||||
| 25. Round | 19/02/2022 | AS Nancy Lorraine | - | USL Dunkerque | 2:0 | ||||
| 26. Round | 26/02/2022 | Havre AC | - | AS Nancy Lorraine | 1:0 | ||||
| 27. Round | 05/03/2022 | AS Nancy Lorraine | - | Grenoble Foot 38 | 0:1 | ||||
| 28. Round | 12/03/2022 | Amiens SC | - | AS Nancy Lorraine | 1:0 | ||||
| 31. Round | 04/04/2022 | AS Nancy Lorraine | - | AC Ajaccio | 0:2 | ||||
| 32. Round | 09/04/2022 | FC Sochaux | - | AS Nancy Lorraine | 1:0 |  |
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| 34. Round | 19/04/2022 | Rodez AF | - | AS Nancy Lorraine | 1:1 | ||||
| 35. Round | 22/04/2022 | AS Nancy Lorraine | - | US Quevilly-Rouen | 0:3 dec. | ||||
| 36. Round | 30/04/2022 | AS Nancy Lorraine | - | Nîmes Olympique | 1:3 | ||||
| 37. Round | 07/05/2022 | Dijon FCO | - | AS Nancy Lorraine | 2:3 | ||||
| 38. Round | 14/05/2022 | AS Nancy Lorraine | - | Pau FC | 2:3 |
France