| 1. Round | 06/08/2021 | US Créteil-Lusitanos | - | US Avranches | 0:0 | ||||
| 2. Round | 13/08/2021 | US Avranches | - | LB Châteauroux | 3:1 | ||||
| 3. Round | 20/08/2021 | FC Sète | - | US Avranches | 1:2 | ||||
| 4. Round | 27/08/2021 | US Avranches | - | FC Bourg-Péronnas | 0:3 | ||||
| 5. Round | 03/09/2021 | CS Sedan | - | US Avranches | 2:0 | ||||
| 6. Round | 10/09/2021 | US Avranches | - | Stade Lavallois | 0:1 | ||||
| 7. Round | 20/09/2021 | US Concarneau | - | US Avranches | 1:3 | ||||
| 8. Round | 24/09/2021 | US Avranches | - | US Boulogne | 1:0 | ||||
| 9. Round | 01/10/2021 | FC Chambly | - | US Avranches | 4:2 | ||||
| 10. Round | 08/10/2021 | US Avranches | - | Red Star FC | 0:6 |  |
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| 11. Round | 22/10/2021 | US Orléans | - | US Avranches | 0:0 | ||||
| 12. Round | 26/10/2021 | US Avranches | - | FC Annecy | 2:0 | ||||
| 13. Round | 05/11/2021 | FC Villefranche Beaujolais | - | US Avranches | 3:0 | ||||
| 34. Round | 13/05/2022 | US Avranches | - | US Créteil-Lusitanos | 2:1 |
France