| 10. Round | 08/03/2019 | San Lorenzo | - | Deportivo Capiatá | 0:1 | ||||
| 11. Round | 18/03/2019 | General Díaz | - | San Lorenzo | 3:3 |  |
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| 12. Round | 23/03/2019 | River Plate | - | San Lorenzo | 2:1 | ||||
| 13. Round | 30/03/2019 | San Lorenzo | - | Club Olimpia | 1:4 | |
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| 14. Round | 04/04/2019 | Club Nacional | - | San Lorenzo | 3:1 | ||||
| 18. Round | 25/04/2019 | San Lorenzo | - | Sol de América | 2:4 | ||||
| 19. Round | 01/05/2019 | Cerro Porteño | - | San Lorenzo | 1:1 | ||||
| 22. Round | 19/05/2019 | San Lorenzo | - | General Díaz | 2:1 |
Paraguay