| 1. Round | 30/07/2022 | Cambridge United | - | Milton Keynes Dons | 1:0 | ||||
| 2. Round | 06/08/2022 | Milton Keynes Dons | - | Sheffield Wednesday | 0:1 | ||||
| 3. Round | 13/08/2022 | Ipswich Town | - | Milton Keynes Dons | 3:0 | ||||
| 6. Round | 27/08/2022 | Morecambe FC | - | Milton Keynes Dons | 0:4 | ||||
| 7. Round | 03/09/2022 | Exeter City | - | Milton Keynes Dons | 1:0 | ||||
| 9. Round | 13/09/2022 | Milton Keynes Dons | - | Bolton Wanderers | 0:2 | ||||
| 14. Round | 08/10/2022 | Shrewsbury Town | - | Milton Keynes Dons | 2:1 | ||||
| 13. Round | 25/10/2022 | Charlton Athletic | - | Milton Keynes Dons | 0:2 | ||||
| 17. Round | 29/10/2022 | Cheltenham Town | - | Milton Keynes Dons | 0:0 | ||||
| 18. Round | 12/11/2022 | Milton Keynes Dons | - | Derby County | 1:3 | ||||
| 19. Round | 19/11/2022 | Barnsley FC | - | Milton Keynes Dons | 3:1 | ||||
| 20. Round | 03/12/2022 | Milton Keynes Dons | - | Burton Albion | 1:1 | ||||
| 26. Round | 24/01/2023 | Milton Keynes Dons | - | Shrewsbury Town | 0:1 | ||||
| 34. Round | 25/02/2023 | Milton Keynes Dons | - | Ipswich Town | 0:1 |  |
Ireland