| 2. Round | 23/07/2022 | Holstein Kiel | - | 1. FC Kaiserslautern | 2:2 | ||||
| 3. Round | 07/08/2022 | 1. FC Kaiserslautern | - | FC St. Pauli | 2:1 | ||||
| 4. Round | 12/08/2022 | 1. FC Kaiserslautern | - | SC Paderborn 07 | 0:1 | ||||
| 5. Round | 21/08/2022 | SpVgg Greuther Fürth | - | 1. FC Kaiserslautern | 1:3 | ||||
| 6. Round | 28/08/2022 | 1. FC Kaiserslautern | - | 1. FC Magdeburg | 4:4 | ||||
| 9. Round | 18/09/2022 | 1. FC Heidenheim 1846 | - | 1. FC Kaiserslautern | 2:2 | ||||
| 10. Round | 02/10/2022 | 1. FC Kaiserslautern | - | Eintracht Braunschweig | 1:1 | ||||
| 12. Round | 16/10/2022 | 1. FC Kaiserslautern | - | Jahn Regensburg | 0:3 | ||||
| 13. Round | 21/10/2022 | Hansa Rostock | - | 1. FC Kaiserslautern | 0:2 | ||||
| 14. Round | 29/10/2022 | 1. FC Kaiserslautern | - | 1. FC Nürnberg | 0:0 | ||||
| 15. Round | 05/11/2022 | Arminia Bielefeld | - | 1. FC Kaiserslautern | 2:3 | ||||
| 16. Round | 08/11/2022 | 1. FC Kaiserslautern | - | Karlsruher SC | 2:0 | ||||
| 17. Round | 11/11/2022 | Fortuna Düsseldorf | - | 1. FC Kaiserslautern | 1:2 |
Germany