| 1. Round | 19/05/2021 | Unión Comercio | - | Cultural Santa Rosa | 2:2 | ||||
| 2. Round | 25/05/2021 | Cultural Santa Rosa | - | Carlos Stein | 1:1 | ||||
| 3. Round | 30/05/2021 | Unión Huaral | - | Cultural Santa Rosa | 0:3 | ||||
| 4. Round | 03/06/2021 | Cultural Santa Rosa | - | Chavelines Juniors | 0:3 | ||||
| 5. Round | 28/06/2021 | Deportivo Coopsol | - | Cultural Santa Rosa | 2:0 | ||||
| 6. Round | 02/07/2021 | Cultural Santa Rosa | - | Juan Aurich | 3:4 | ||||
| 7. Round | 07/07/2021 | Pirata | - | Cultural Santa Rosa | 2:3 | ||||
| 8. Round | 11/07/2021 | Cultural Santa Rosa | - | Comerciantes Unidos | 2:2 | ||||
| 9. Round | 16/07/2021 | Atlético Grau | - | Cultural Santa Rosa | 0:0 | ||||
| 10. Round | 22/07/2021 | Cultural Santa Rosa | - | Santos FC | 3:0 |  |
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| 11. Round | 29/07/2021 | Llacuabamba | - | Cultural Santa Rosa | 1:1 |
Uruguay