4. Round | 20/02/2021 | Guaraní | - | Club Olimpia | 0:3 | ||||
5. Round | 28/02/2021 | Club Olimpia | - | Cerro Porteño | 2:0 | ||||
6. Round | 06/03/2021 | Sol de América | - | Club Olimpia | 0:2 | ||||
7. Round | 10/03/2021 | Club Olimpia | - | Club Nacional | 1:4 | ||||
8. Round | 14/03/2021 | Sportivo Luqueño | - | Club Olimpia | 4:2 | ||||
9. Round | 21/03/2021 | Club Olimpia | - | River Plate | 5:1 | ||||
10. Round | 04/04/2021 | Libertad | - | Club Olimpia | 0:1 | ||||
11. Round | 11/04/2021 | Club Olimpia | - | 12 de Octubre de Itauguá | 2:2 | ||||
12. Round | 16/04/2021 | Guaireña FC | - | Club Olimpia | 1:2 | ||||
13. Round | 25/04/2021 | Club Olimpia | - | Guaraní | 2:1 | ||||
14. Round | 02/05/2021 | Cerro Porteño | - | Club Olimpia | 2:0 | ||||
15. Round | 09/05/2021 | Club Olimpia | - | Sol de América | 3:3 | ||||
18. Round | 30/05/2021 | River Plate | - | Club Olimpia | 1:2 |