| 5. Round | 01/03/2025 | Real Santander | - | Jaguares de Córdoba | 0:1 | ||||
| 6. Round | 09/03/2025 | Real Cartagena | - | Real Santander | 2:0 | ||||
| 7. Round | 17/03/2025 | Real Santander | - | Leones FC | 1:0 |  |
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| 8. Round | 22/03/2025 | Boca Juniors de Cali | - | Real Santander | 0:1 | ||||
| 9. Round | 31/03/2025 | Real Santander | - | Cúcuta Deportivo | 2:1 |
Colombia