| 2. Round | 23/01/2021 | Atlético FC | - | Real Cartagena | 3:0 | ||||
| 3. Round | 01/02/2021 | Real Cartagena | - | Barranquilla FC | 1:0 | ||||
| 7. Round | 19/02/2021 | Real Cartagena | - | Deportes Quindío | 2:3 | ||||
| 8. Round | 27/02/2021 | Orsomarso SC | - | Real Cartagena | 3:3 | ||||
| 9. Round | 03/03/2021 | Real Cartagena | - | Boca Juniors de Cali | 1:1 |
Colombia