1. Round 14/08/2021 RCD Mallorca - Real Betis 1:1 yellow card
2. Round 20/08/2021 Real Betis - Cádiz CF 1:1 Goal
3. Round 28/08/2021 Real Betis - Real Madrid 0:1
5. Round 19/09/2021 Real Betis - Espanyol Barcelona 2:2
6. Round 23/09/2021 CA Osasuna - Real Betis 1:3 Goal
7. Round 26/09/2021 Real Betis - Getafe CF 2:0
8. Round 03/10/2021 Villarreal CF - Real Betis 2:0 yellow card
10. Round 24/10/2021 Real Betis - Rayo Vallecano 3:2 Goal
11. Round 27/10/2021 Real Betis - Valencia CF 4:1 Goal
12. Round 31/10/2021 Atlético Madrid - Real Betis 3:0
13. Round 07/11/2021 Real Betis - Sevilla FC 0:2
14. Round 21/11/2021 Elche CF - Real Betis 0:3 Goal yellow card
15. Round 28/11/2021 Real Betis - Levante UD 3:1 GoalGoalGoal
16. Round 04/12/2021 FC Barcelona - Real Betis 0:1 Goal
17. Round 12/12/2021 Real Betis - Real Sociedad 4:0 Goal
18. Round 19/12/2021 Athletic Bilbao - Real Betis 3:2 Goal
19. Round 02/01/2022 Real Betis - RC Celta 0:2
21. Round 18/01/2022 Real Betis - CD Alavés 4:0 Goal
22. Round 21/01/2022 Espanyol Barcelona - Real Betis 1:4 yellow card
23. Round 06/02/2022 Real Betis - Villarreal CF 0:2
25. Round 20/02/2022 Real Betis - RCD Mallorca 2:1 yellow card
27. Round 06/03/2022 Real Betis - Atlético Madrid 1:3
28. Round 13/03/2022 Real Betis - Athletic Bilbao 1:0
29. Round 20/03/2022 RC Celta - Real Betis 0:0
30. Round 03/04/2022 Real Betis - CA Osasuna 4:1 GoalGoal
31. Round 09/04/2022 Cádiz CF - Real Betis 1:2
32. Round 15/04/2022 Real Sociedad - Real Betis 0:0
33. Round 19/04/2022 Real Betis - Elche CF 0:1
34. Round 02/05/2022 Getafe CF - Real Betis 0:0
35. Round 07/05/2022 Real Betis - FC Barcelona 1:2
36. Round 10/05/2022 Valencia CF - Real Betis 0:3
37. Round 15/05/2022 Real Betis - Granada CF 2:0 GoalGoal
38. Round 20/05/2022 Real Madrid - Real Betis 0:0