| 1. Round | 24/07/2021 | Leones FC | - | Orsomarso SC | 1:0 | ||||
| 2. Round | 02/08/2021 | Orsomarso SC | - | Llaneros FC | 0:2 | ||||
| 3. Round | 07/08/2021 | Tigres FC | - | Orsomarso SC | 1:2 | ||||
| 4. Round | 16/08/2021 | Orsomarso SC | - | Barranquilla FC | 0:0 |  |
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| 5. Round | 20/08/2021 | Bogotá FC | - | Orsomarso SC | 3:0 | ||||
| 6. Round | 28/08/2021 | Orsomarso SC | - | Atlético FC | 1:2 | |
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| 8. Round | 11/09/2021 | Valledupar FC | - | Orsomarso SC | 1:2 | |
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| 9. Round | 21/09/2021 | Orsomarso SC | - | Boyacá Chicó | 2:1 | ||||
| 10. Round | 25/09/2021 | Fortaleza FC | - | Orsomarso SC | 4:0 | |
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| 11. Round | 02/10/2021 | Orsomarso SC | - | Real Santander | 3:1 |
Colombia