| 1. Round | 06/08/2022 | Vysočina Jihlava [Youth B] | - | 1. FC Slovácko [Youth B] | 2:1 | ||||
| 2. Round | 13/08/2022 | 1. FC Slovácko [Youth B] | - | FK Pardubice [Youth B] | 3:1 | ||||
| 3. Round | 19/08/2022 | Banik Ostrava [Youth B] | - | 1. FC Slovácko [Youth B] | 4:3 | ||||
| 4. Round | 27/08/2022 | 1. FC Slovácko [Youth B] | - | Dynamo České Budějovice [Youth B] | 4:0 | ||||
| 8. Round | 30/08/2022 | Viktoria Plzeň [Youth B] | - | 1. FC Slovácko [Youth B] | 2:0 | ||||
| 5. Round | 03/09/2022 | Sigma Olomouc [Youth B] | - | 1. FC Slovácko [Youth B] | 1:1 | ||||
| 6. Round | 10/09/2022 | AC Sparta Praha [Youth B] | - | 1. FC Slovácko [Youth B] | 3:0 | ||||
| 12. Round | 21/10/2022 | MFK Karviná [Youth B] | - | 1. FC Slovácko [Youth B] | 0:3 | ||||
| 14. Round | 26/10/2022 | FC Zlín [Youth B] | - | 1. FC Slovácko [Youth B] | 1:1 |  |
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| 13. Round | 29/10/2022 | 1. FC Slovácko [Youth B] | - | FK Příbram [Youth B] | 9:2 | ||||
| 21. Round | 07/04/2023 | 1. FC Slovácko [Youth B] | - | AC Sparta Praha [Youth B] | 0:2 |
Czech Republic