| 1. Round | 22/01/2020 | Blooming | - | Real Santa Cruz | 1:1 | ||||
| 2. Round | 26/01/2020 | Real Santa Cruz | - | The Strongest | 3:2 | ||||
| 4. Round | 02/02/2020 | Real Potosí | - | Real Santa Cruz | 2:1 |  |
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| 3. Round | 05/02/2020 | Real Santa Cruz | - | Club San José | 1:1 | ||||
| 6. Round | 14/02/2020 | Jorge Wilstermann | - | Real Santa Cruz | 0:0 | ||||
| 7. Round | 16/02/2020 | Real Santa Cruz | - | Oriente Petrolero | 1:5 | ||||
| 8. Round | 22/02/2020 | Atlético Palmaflor | - | Real Santa Cruz | 2:1 |  |
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| 21. Round | 19/12/2020 | Real Santa Cruz | - | Atlético Palmaflor | 2:1 | |
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| 23. Round | 24/12/2020 | Real Santa Cruz | - | Royal Pari | 2:4 | ||||
| 25. Round | 29/12/2020 | Real Santa Cruz | - | CD Guabirá | 4:4 | ||||
| 26. Round | 31/12/2020 | Club Aurora | - | Real Santa Cruz | 1:1 |
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