6. Round | 16/08/2021 | Talleres de Córdoba | - | San Lorenzo | 2:0 | ||||
7. Round | 22/08/2021 | San Lorenzo | - | Argentinos Juniors | 0:1 | ||||
8. Round | 26/08/2021 | Estudiantes | - | San Lorenzo | 2:0 | ||||
9. Round | 30/08/2021 | San Lorenzo | - | Patronato de Paraná | 3:0 | ||||
10. Round | 04/09/2021 | Platense | - | San Lorenzo | 1:1 | ||||
11. Round | 13/09/2021 | San Lorenzo | - | Racing Club | 1:1 | ||||
12. Round | 20/09/2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
13. Round | 26/09/2021 | San Lorenzo | - | Defensa y Justicia | 2:1 | ||||
14. Round | 02/10/2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | ||||
16. Round | 18/10/2021 | River Plate | - | San Lorenzo | 3:1 | ||||
17. Round | 20/10/2021 | San Lorenzo | - | Lanús | 1:3 | ||||
18. Round | 24/10/2021 | Huracán | - | San Lorenzo | 2:1 | ||||
19. Round | 31/10/2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
20. Round | 07/11/2021 | Vélez Sarsfield | - | San Lorenzo | 2:1 | ||||
21. Round | 19/11/2021 | San Lorenzo | - | Gimnasia de La Plata | 0:1 | ||||
22. Round | 23/11/2021 | Aldosivi | - | San Lorenzo | 2:0 | ||||
23. Round | 30/11/2021 | San Lorenzo | - | Sarmiento de Junín | 1:0 | ||||
25. Round | 12/12/2021 | San Lorenzo | - | Newell's Old Boys | 3:2 |