| 2. Round | 02/05/2022 | Houston Dash [Women] | - | San Diego Wave FC [Women] | 0:1 | ||||
| 2. Round | 19/05/2022 | Racing Louisville [Women] | - | San Diego Wave FC [Women] | 1:0 | ||||
| 2. Round | 29/05/2022 | OL Reign [Women] | - | San Diego Wave FC [Women] | 1:0 | ||||
| 3. Round | 19/06/2022 | NJ/NY Gotham FC [Women] | - | San Diego Wave FC [Women] | 0:3 |  |
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| 4. Round | 03/07/2022 | San Diego Wave FC [Women] | - | Washington Spirit [Women] | 2:1 | ||||
| 4. Round | 10/07/2022 | Angel City FC [Women] | - | San Diego Wave FC [Women] | 2:1 | ||||
| 4. Round | 16/07/2022 | San Diego Wave FC [Women] | - | Racing Louisville [Women] | 0:0 | ||||
| 5. Round | 14/08/2022 | San Diego Wave FC [Women] | - | Orlando Pride [Women] | 0:1 | ||||
| 6. Round | 01/10/2022 | San Diego Wave FC [Women] | - | NC Courage [Women] | 0:0 |
Germany