1. Round 06/03/2016 Portland Timbers - Columbus Crew 2:1
1. Round 13/03/2016 Columbus Crew - Philadelphia Union 1:2
1. Round 19/03/2016 Chicago Fire - Columbus Crew 0:0
2. Round 03/04/2016 FC Dallas - Columbus Crew 1:1
2. Round 09/04/2016 Impact de Montréal - Columbus Crew 2:0
2. Round 17/04/2016 Columbus Crew - New York City FC 3:2 red card
2. Round 24/04/2016 Columbus Crew - Houston Dynamo 1:0
2. Round 30/04/2016 Seattle Sounders - Columbus Crew 1:0
3. Round 08/05/2016 Columbus Crew - Impact de Montréal 4:4
3. Round 15/05/2016 Columbus Crew - Colorado Rapids 1:1
3. Round 21/05/2016 Toronto FC - Columbus Crew 0:0
3. Round 29/05/2016 Columbus Crew - Real Salt Lake 4:3
4. Round 02/06/2016 Philadelphia Union - Columbus Crew 3:2
4. Round 19/06/2016 Columbus Crew - Impact de Montréal 0:0
4. Round 26/06/2016 Columbus Crew - New York RB 1:1
5. Round 04/07/2016 Sporting Kansas City - Columbus Crew 3:2
5. Round 10/07/2016 New England Revolution - Columbus Crew 3:1
5. Round 14/07/2016 Columbus Crew - Toronto FC 1:1
5. Round 17/07/2016 Columbus Crew - D.C. United 1:1
5. Round 24/07/2016 Columbus Crew - Orlando City 2:2
5. Round 01/08/2016 Toronto FC - Columbus Crew 3:0 yellow card
6. Round 14/08/2016 Columbus Crew - New York City FC 3:3
6. Round 21/08/2016 New England Revolution - Columbus Crew 0:2
6. Round 25/08/2016 Columbus Crew - Philadelphia Union 1:2
6. Round 28/08/2016 Columbus Crew - San Jose Earthquakes 2:0
7. Round 04/09/2016 Los Angeles Galaxy - Columbus Crew 2:1
7. Round 11/09/2016 Columbus Crew - Vancouver Whitecaps 1:3
7. Round 18/09/2016 Orlando City - Columbus Crew 1:4
7. Round 26/09/2016 Columbus Crew - New England Revolution 2:0 yellow card
7. Round 29/09/2016 D.C. United - Columbus Crew 3:0
8. Round 02/10/2016 Columbus Crew - Chicago Fire 3:0
8. Round 14/10/2016 Chicago Fire - Columbus Crew 2:2
8. Round 16/10/2016 New York RB - Columbus Crew 3:2
8. Round 23/10/2016 New York City FC - Columbus Crew 4:1