| 1. Round | 07/08/2022 | NEC Nijmegen | - | FC Twente | 0:1 |  |
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| 2. Round | 14/08/2022 | FC Volendam | - | NEC Nijmegen | 1:4 |  |
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| 4. Round | 26/08/2022 | NEC Nijmegen | - | FC Groningen | 1:1 | ||||
| 3. Round | 01/09/2022 | AZ Alkmaar | - | NEC Nijmegen | 1:1 | ||||
| 5. Round | 04/09/2022 | sc Heerenveen | - | NEC Nijmegen | 0:0 | ||||
| 6. Round | 10/09/2022 | NEC Nijmegen | - | Fortuna Sittard | 1:1 | ||||
| 7. Round | 16/09/2022 | FC Utrecht | - | NEC Nijmegen | 0:0 | ||||
| 8. Round | 02/10/2022 | NEC Nijmegen | - | Feyenoord | 1:1 | ||||
| 9. Round | 08/10/2022 | NEC Nijmegen | - | SBV Excelsior | 1:1 | ||||
| 10. Round | 16/10/2022 | Sparta Rotterdam | - | NEC Nijmegen | 2:0 | ||||
| 11. Round | 23/10/2022 | NEC Nijmegen | - | Go Ahead Eagles | 3:3 | ||||
| 15. Round | 08/01/2023 | NEC Nijmegen | - | AFC Ajax | 1:1 | ||||
| 17. Round | 21/01/2023 | NEC Nijmegen | - | FC Emmen | 3:1 | ||||
| 18. Round | 25/01/2023 | Feyenoord | - | NEC Nijmegen | 2:0 | ||||
| 19. Round | 28/01/2023 | NEC Nijmegen | - | Sparta Rotterdam | 1:1 |
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